Hyperoxia and acute lung injury

Hyperoxia and acute lung injury.

TO THE EDITOR: The review by Matute-Bello et al. (15) has misleading and potentially dangerous statements concerning the role of hyperoxia in human acute lung injury (ALI). Table 4 states “in normal human lungs, 100% oxygen has not induced lung injury . . . ” The text states that most mammalian species develop respiratory distress and die with exposure to 100% oxygen, but the “same findings hav...

Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats

Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI).   Materials ...

Retracted: Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats

Asiaticoside attenuates hyperoxia-induced lung injury in vitro andin vivo

Objective(s): Asiaticoside (AS) displays anti-inflammation, and anti-apoptosis effect, but the role of AS in hyperoxia-induced lung injury (HILI) treatment is undefined. Therefore, the aim of this study was to investigate the effects of AS on HILI on premature rats and alveolar type II (AEC II) cells.Materials and Methods: Sprague-Dawley...

Deletion of ASK1 Protects against Hyperoxia-Induced Acute Lung Injury

Apoptosis signal-regulating kinase 1 (ASK1), a member of the MAPK kinase kinase kinase (MAP3K) family, is activated by various stimuli, which include oxidative stress, endoplasmic reticulum (ER) stress, calcium influx, DNA damage-inducing agents and receptor-mediated signaling through tumor necrosis factor receptor (TNFR). Inspiration of a high concentration of oxygen is a palliative therapy wh...